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Information × Registration Number 0217U000656, 0112U002196 , R & D reports Title Molecular-genetic mechanisms of paraneoplastic syndrome manifestation associated with tumor angiogenesis, and possible approaches of morbid change correction popup.stage_title Head Solyanyk Galyna Ivanivna, Registration Date 17-02-2017 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 For the first time a direct link between the level of circulating vascular endothelial growth factor (VEGF) and the degree of manifestation of hematogenous paraneoplastic syndrome was identified. Paraneoplastic syndrome accompanied by inhibition of bone marrow hematopoiesis, violation of the morphological structure and functional activity of the kidneys, the development of immunopathological reactions. VEGF inhibitors can be used for the correction of tumor-associated anemia and thrombocytopenia in order to increase the effectiveness of treatment of cancer patients and improve their quality of life. Besides, a number of approaches designed to correct these disorders has been developed. In particular, carbohydrate enterosorbents and cancer vaccines were able to eliminate the various manifestations of paraneoplastic syndrome. Enterosorption reduces paraneoplastic anemia, thrombocytopenia; improves the liver functional activity Allogeneic cancer vaccine prevents the thymus involution, increases the activity of nonspecific antitumor immunity effectors. Selection of cancer vaccines (autologous or allogeneic) is advantageously carried out taking into account the manifestations of tumor-associated anemia Product Description popup.authors Бардахівська К.І. Воєйкова І.М. Горбик Г.В. Діденко Г.В. Караман О.М. Колесник Д.Л. Масленний В.М. Ніколаєв В.Г. Потебня Г.П. Пясковська О.М. Сарнацька В.В. Соляник Г,І. Федорчук О.Г. Федосова Н.І. Хмара В.А. Юшко Л.О. popup.nrat_date 2020-04-02 Close