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Information × Registration Number 0217U000864, 0114U001550 , R & D reports Title The role of allelic polymorphism of biotransformation system genes in the pathogenesis of metabolik disorders in children with ecopathology popup.stage_title Head Hnateiko Oleh Zinovijovych, Registration Date 14-03-2017 Organization Scientific-research institute of Hereditary pathology popup.description2 Presence eco disease in children, which is non-specific multisystem nature, appearing syndromes environmental maladjustment and xenogenic intoxication. A high sensitization of children to chromium salts, cesium, iron, magnesium and titanium in terms of specific lysis of leukocytes. Proven increase in the concentration of immunoglobulin major classes A, M, G in serum of children, leading to an imbalance of the immune resistance of the organism. High activity of GST, lack of activity and ADG decreased activity NAT evidence of depletion mechanisms of detoxification. Most children with polluted areas set high daily salt excretion in the urine, indicating that the reduction of compensatory mechanisms. Shown hipokaltsiemiya reliable and hypercalciuria and fluctuations in BMD in the majority of children surveyed. Features genotype C / C (113 His / His 113) polymorphic locus T337S mERNH gene marker are high, we ekodeterminovanoyi predisposition to the emergence of disease. Product Description popup.authors Іськів Марьяна Юріївна Виштак Наталя Валентинівна Галабуда Наталя Кеч Наталя Романівна Ковалів Ірина Богданівна Косминіна Неля Станіславівна Кравець Жульєта Романівна Лук'яненко Наталія Сергіїївна Лучак Марта Володимирівна Петріца Назар Андрійович Чайковська Ганна Степанівна popup.nrat_date 2020-04-02 Close