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Information × Registration Number 0217U000875, 0114U002512 , R & D reports Title To develop best practices for transplantation use of cryopreserved amniotic membrane and allogeneic limbal stem cells of the cornea on the basis of the mechanisms of their effects on the peculiarities of inflammation and regeneration in the treatment of corneal pathologies and determine their effectiveness popup.stage_title Head Drozhzhina Galina I., Registration Date 16-03-2017 Organization The Filatov Research Institute of Diseases and Tissue Therapy popup.description2 Whenusinginlaytechniqueofamnioticmembranetransplantation, cryopreservedaccordingtothenewtechnology, intheexperimentalbacterialkeratitistreatmentifcomparedwiththeonlaytechniqueitwasobservedmorepronouncedinflammatoryprocessaccompaniedbytheinflammatorygranulomasformationaroundcornealsuturesandmarkedexpressionofimmunohistochemicalmarkers Ki-67, SD 68, MMP - 9. Inbothanimalgroupsmajorityofvimentin-expressingcellsisdeterminedintheearlystagesofcornealregenerationandiskeptinseveralkeratinocytesoffullydifferentiatedcornealepithelium. Atthesamedepthofcornealbacterialinfectiousprocessonlaytechniqueofamnioticmembranetransplantationshouldbeconsideredasoneofthebeastchoice. Ontheneurotrophickeratitismodelitwasshownthatsubconjunctivalinjectionofhumancorneallimbalepithelialcellsallogeneicculturesuspension, whichcontains 1% ofstemcells, acceleratescornealregeneration. Ontheneurotrophickeratitismodelitwasshown a goodtoleranceofallogeneicmonolayerofcryopreservedhumancorneallimbalstemcellsonamnioticmembranesubstratetransplantation, noincompatibilityreactions, localirritationtotheeyetissue. Product Description popup.authors Іванова Ольга Миколаївна Івановська Олена Володиміровна Артьомов Олександр Валентинович Віт Валерій Вікторович Гайдамака Тетяна Борисівна Головченко Валентина Григорівна Гутник Віктор Миколайович Драгомірецька Олена Іванівна Дрожжина Галина Іванівна Коган Борис Михайлович Коломійчук Сергій Георгієвич Леус Микола Федорович Мальцев Єдуард Валентінович Осташевский Віктор Леонардович Папондопуло А.Г. Середа Катеріна Віталіївна Тройченко Людмила Федорівна Усов Володимир Якович Філоненко В.В, Храменко Наталія Іванівна popup.nrat_date 2020-04-02 Close
R & D report
To develop best practices for transplantation use of cryopreserved amniotic membrane and allogeneic limbal stem cells of the cornea on the basis of the mechanisms of their effects on the peculiarities of inflammation and regeneration in the treatment of corneal pathologies and determine their effectiveness
Head: Drozhzhina Galina I.. To develop best practices for transplantation use of cryopreserved amniotic membrane and allogeneic limbal stem cells of the cornea on the basis of the mechanisms of their effects on the peculiarities of inflammation and regeneration in the treatment of corneal pathologies and determine their effectiveness. (popup.stage: ). The Filatov Research Institute of Diseases and Tissue Therapy. № 0217U000875
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Updated: 2026-03-23


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