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Information × Registration Number 0217U000957, 0114U000908 , R & D reports Title Pharmacologycal modulation of retinal ganglion cells electrical activity in norm and at patological states modelling. popup.stage_title Head Fedulova Svitlana A., Registration Date 21-03-2017 Organization International center of molecular physiology popup.description2 On isolated retina preparation electrophysiological and pharmacological properties of rat retinal ganglion cells (RGC) were studied using whole cell techniques in voltage clamp mode. Characteristics of voltage-depended Kv3.1/Kv3.2 potassium current were determined. It was shown that hexamethonium inhibit relatively high amplitude (40-100 pA) ongoing postsynasptic currents in 60% of RGC. It was established that at experimentally-induced diabetes in rat RGCs resting membrane potential, amplitude and frequency of ongoing postsynaptic currents are reduced. Keywords: retinal ganglion cells, voltage-dependent current, ongoing activity, nicotinic acetylcholine receptors, experimentally-induced diabetes. Product Description popup.authors Веселовська Н.М. Мартинюк Н.Я. Маслов В.Ю. popup.nrat_date 2020-04-02 Close