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Information × Registration Number 0217U000970, 0112U000614 , R & D reports Title Changes in expression of genes and activity of enzymes involved in carbohydrate and energy metabolism in malignant cells as mean of tumor growth suppression. popup.stage_title Head Sibirny Andriy Andrijovych, Registration Date 23-03-2017 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 A new innovative approach for cancer treatment based on inhibition of energy metabolism of tumor cells was developed. Artificial restriction of tumor cells into carbohydrates should greatly slow their growth, while normal cells will compensate for the absence of glucose from fat and protein. Special diet poor in carbohydrates and fat and enriched with proteins was used and specific inhibitors of gluconeogenesis - metformin and glibenclamide, which is already established in the treatment of diabetes were taken. During the the experiment it was shown that the usage of low-carbohydrate diet allowed significantly (1.6 times) prolong the life of the animal with lymphoma NK / Ly and leukemia L1210. The tumor volume of these experimental animals also was inhibited.. The proposed diet does not show any side effects on the organism of experimental animals and can be used without restrictions. The usage of antidiabetic drug metformin and glibenclamide with diet further prolonged the life span of animals with both models of tumor - 2.2 times compared to the control group. In this case, there was a significant (90%) reduction in ascites fluid volume in mice with lymphoma NK / Ly and improvement of morphophysiological indexes and increase in tumor growth.5481 Product Description popup.authors Барська М.Л. Бобак Я.П. Борецький Ю.Р. Вовк О.І. Гайда Г.З. Гончар М.В. Закальський А.Є. Курліщук Ю.В. Легка Л.В. Маєвська О.М. Панчук Р.Р. Рачкевич Н.О. Скорохід Н.Р. Смуток О.В. Стасик О.В. Стойка Р.С. Фаюра Л.Р. Федорович Д.В. Чумак В.В. popup.nrat_date 2020-04-02 Close