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Information × Registration Number 0217U000997, 0114U002152 , R & D reports Title Іodine status and antioxidant system activity in the presence of iodine deficiency in the thyroid gland popup.stage_title Head Kravchеnko Victor Ivanovich, Registration Date 28-03-2017 Organization State institution "V.P. Komisarenko Institute of Endocrynology and Metabolism of the National Academy of Medical Science of Ukraine" popup.description2 Object of study: thyroid status, iodine status among the population of Northern regions of Ukraine, thyroid pathology: nodular goiter, cancer; impact of biologically active elements on thyroid status. Aim of study: establish the features of macro- and microelements' intake among residents of Northern regions of Ukraine; assess the links between thyroid pathology occurrence and the indices of macro- and microelements' intake. Methods of study: randomized sampling of study participants based on their place of residence, age and gender; cerium-arsenite method of urinary iodine content. Study by method of atomic emission spectrometry of blood plasma content of microelements Zn, Fe, Cu, Se, and macroelements Mg and Ca. A retrospective analysis of the data obtained in a large study cohort (about 10 thousand subjects) from Kyiv, Zhytomyr, Chernihiv regions, and Kyiv City over the last 15 years has shown the presence of stable deficiency of iodine intake among the population of Northern regions of Ukraine.A study of iodine status of the population, conducted at present, in terms of urinary ioduria and goiter frequency in Zhytomyr, Chernihiv (Chernihiv City) and Kyiv regions, and Kyiv City, has revealed a frequency of subjects with medium and mild iodine deficiency ranged from 20 to 56% of study subjects, suggesting unresolved issue of iodine deficiency prevention. The frequency of goiter cases among study patients also suggested the presence of mild iodine deficiency. According to ultrasound investigation, it ranged from 8 to 45%. The problem of iodine deficiency in the dietary structure of the population of Northern regions of Ukraine remains unresolved.A study has been conducted, of macro- and microelements' intake in patients' groups with thyroid pathology (nodular goiter, thyroid cancer and autoimmune thyroiditis) and in a control group of Chernihiv, Zhytomyr, and Kyiv regions of Ukraine. In Chernihiv region, 85 subjects aged 30-46 years have had examination, of which 45 formed an experimental group which included 25 patients with diagnosed nodular goiter and 20 with thyroid cancer. In Zhytomyr region, 88 subjects have been examined, of which 40 from the control and 48 from the experimental group; 16 patients with thyroid cancer, 16 with diagnosed nodular goiter, and 16 with autoimmune thyroiditis. In Kyiv region, 94 subjects have been examined, of which 45 from the control group and 49 from the experimental one: 17 patients with thyroid cancer, 16 with diagnosed nodular goiter and 16 with autoimmune thyroiditis. It has been established that the development of thyroid pathology was associated with abnormal blood content of micro- (I, Zn, Se) and macroelements (Mg, Ca). A decrease in iodine, zinc and selenium content in blood plasma, which are the main elements that form the enzymes of antioxidant system, are perhaps one of the factors of cause-effect relationship with the occurrence of thyroid diseases. Determination of a decrease in calcium and magnesium in nodular goiter and a surplus of these macroelements in malignant thyroid tumors, are essential for the differential diagnosis of benign and malignant thyroid tumors, as well as for an adequate tactics of treatment of this pathology. Degree of introduction: the articles, lectures. Application domain: endocrinology Product Description popup.authors Бояр Т.А. Ковтун В.А. Кравченко Віктор Іванович Лузанчук І.А. Постол С.В. popup.nrat_date 2020-04-02 Close