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Registration Number

0217U001010, 0116U006539 , R & D reports

Title

Identification of molecular markers for early diagnostics of tumors and characterization of the mechanisms of upregulated expression of chitinase 3 like 1

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Head

Balynska Olena Viktorivna,

Registration Date

05-01-2017

Organization

Institute of Molecular Biology and Genetics of NASU

Description

The aim of this project is to reveal key factors that determine progression of different types of tumors and can be effective diagnostic and prognostic markers of tumor development. Using meta-analysis of the data from databases and from previous results obtained by the authors of this project, potential markers (i.e. abnormally methylated DNA and differentially expressed genes) of kidney and brain cancers will be selected. Epigenetic state of target genes from cell-free circulating DNA in blood from healthy controls and kidney cancer patients before and after surgery will be determined. In the scope of present study we want to characterize (the functions and mechanism of action - par example) of Chitinase 3 like 1 protein (CHI3L1), which was shown to be overexpressed in high malignancy grades of brain tumors. Besides we are aimed to identify the potential receptor of CHI3L1 to understand in more details the mechanism of its action. Taken together obtained data potentially can be used for the design of theurapeutic treatment with anti-angiogenic drugs, which specifically act towards the expression and functioning of CHI3L1 in tumor cells

Product Description

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Єршов А.В.
Арешков П.О.
Мордерер Д.Є.
Скрипкіна І.Я.