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Information × Registration Number 0217U001248, 0116U002826 , R & D reports Title The development of bioactive materials for directional impact on pro- and antioxidant systems of the aging organism popup.stage_title Head Nikitchenko Yuri Victorovich, Кандидат технічних наук Registration Date 01-02-2017 Organization Kharkov National University named after V.N. Karazin popup.description2 Objects of research - physical and chemical properties of nanoparticles gadolinium ortovanadates, dioxide of cerium on the state of prooxidant-antioxidant system, survival and physiological indicators of aging organism by natural aging. Methods: spectrophotometry, fluorymetry, polarography method of dynamic light scattering, biochemical, physiological, statistic methods. The main results and conclusions: Given the low pass investigated in vitro, inhibit and divide the processes of respiration and oxidative phosphorylation, depolyaryzuyut of mitochondrial membrane and reduce the level of ATP in organelles. For the first time found that the nanoparticles GdVO4: Eu3 + is active, which is like glutathione peroxidase activity. Long-term (within 10-12 months) use low pass GdVO4: Eu3 +, CeO 2 and metformin rats aged 22-23 months leads to slow reduction in the concentration of thyroxine in the blood and slow accumulation of free radical oxidation of lipids in the blood and liver of experimental rats, as well as leveling dependent on age and decrease glutathione peroxidase activity and activity of glutaredoxin. Found that the median survival of control animals and animals treated with CeO 2 NPs, metformin and bass GdVO4: Eu3 + was observed at 910, 960, 990, 1010 day old animals, respectively. These data lead to the conclusion that GdVO4 ? Eu3 + can be the basis for the development of drugs geroprotective action or tools that can improve the quality of life of the aging body Product Description popup.authors В. Бондар В. Дзюба Г. Шеремет М. Ковальова О. Козлова popup.nrat_date 2020-04-02 Close