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Information × Registration Number 0217U001424, 0114U000387 , R & D reports Title The study of immunological mechanisms of activation and persistence of herpesviruses in patients with lesions of the nervous system and optimization of immunotropic therapy popup.stage_title Head Rudenko Antonina, Доктор медичних наук Registration Date 13-02-2017 Organization The L.V.Gromaschevskyi Scientific and Research Institute of Epidemiology and Infectious Diseases popup.description2 The aim was improve etiopathogenetical therapy of patients with neurological injuries, caused by herpeviruses, to prevent adverse effects, recurrence of the disease and improve quality of life based on analysis of humoral immunity of regulatory and activated T cells, autoimmune reactions in the activation and persistence of herpesviruses , . Methods: comprehensive clinical examination of patients in the dynamics of the disease, MRI of the brain and spinal cord, ECG, indicators of immune status, cEEG. The study involved 493 patientsThe aim was based on analysis of humoral immunity status, level of activated and regulatory T-lymphocytes, autoimmune reactions in the activation and persistence of herpes virus infection in patients with neurological lesions, improve etiopathogenic therapy to prevent adverse effects, recurrence of the disease and improve quality of life. Research Methods - a comprehensive clinical examination of patients in the course of the disease, an MRI of the brain and spinal cord, ECG, indicators of immune status, cEEG. The object of study - 493 patients. As a result of this work revealed that the introduction of the complex therapy of patients with herpes nervous system drug interferon-?2b, reduces the time of recovery for 4-6 days against the backdrop of normalization of cellular immune response and reduce autoimmune aggression. First used in the treatment of human leukocyte dialysate Imodynu as in patients with herpesvirus activation, as observed persistence of a significant increase of the functional activity of neutrophils (primarily due to myeloperoxidase) and reduce autoimmune reactions. For the first time you turn the complex drug therapy "Propes" is set to grow content of T-lymphocytes, T-helper cells and active T lymphocytes; while the content of B cells and natural killer cells decreased slightly, indicating the activation of antiviral immunity in response to the activation of viral infection. It has been shown that the inclusion of drug Halavit to the complex therapy of herpesvirus nervous system contributes to the positive dynamics of the normalization of clinical and immunological parameters. Proven therapeutic efficacy of medicinal Fosfohliv with liver disease in patients with herpes neuroinfections. In establishing the etiology resistant to treatment optic neuritis found them Lyme boreliozna nature combined with herpes virus infection or in the background. Changes cEEG at Lyme borreliosis characterize inclusion in the pathological process of certain parts of the brain. Treatment of Lyme borreliosis polyoxidonium to include the drug is effective, which is reflected positive changes of the immune system. For the first time improved diagnosis and treatment of recurrent obstructive bronchitis on the background of herpes infections in children. Product Description popup.authors Дьяченко П.А. Луценко В.Ю. Муравська Л.В. Пархомець Б.А. Руденко Антоніна Олексіївна Сидорова Ж.П. Юхименко О.О. popup.nrat_date 2020-04-02 Close