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Information × Registration Number 0217U001503, 0115U000502 , R & D reports Title Рreparation, screening and assessment antitoxic properties of low molecular weight substances from microalgae popup.stage_title Head Bozhkov A.I., Registration Date 21-02-2017 Organization Kharkov National University named after V.N. Karazin popup.description2 The object of study - low molecular weight substances from the cells of algae, fungi, yeast and colostrum. Purpose - to develop technology for low molecular substances from Dunaliella viridis cells with induced resistance to heavy metals and assessment of their impact on resistance to heavy metals on different schemes of administration to animals. Methods - culture of bone marrow cells, physiological, biochemical, immunological, statistical methods of evaluation. Multiple sequential administration of relatively small doses of toxicants (copper sulfate) at a dose of 30-33% of the lethal form a resistance to lethal doses of the same toxins, that form hormesis effect in animals, algae and other organisms. Low molecular weight components (NC), which include proteins, sugars, minerals and other components of cells, cells isolated from algae, fungi or cow colostrum have antioxidant, antitoxic properties regardless of their origin. Preliminary administration to animals of NK increased the effect of hormesis. For the first time found that resistance to exposure to toxic concentrations of copper ions can take place while ensuring their non-toxic NC. IPC can provide a treatment of liver fibrosis. The results allowed to formulate a common concept of physical and chemical regulation of body resistance to the toxic effects of heavy metals. The essence of the concept: NC composed of biologically active compounds affect the characteristics of the redox system cells and the organism as a whole and to other individual regulatory mechanisms simultaneously, which creates a new metabolic pattern, with increased regulatory signals by synchronizing different regulatory systems. This concept allows the use of integrated systems of regulation of biological systems that can be used in solving the problems of resistance of the organism. The developed membrane technology for NK cell cultures of microalgae, yeast, fungi and colostrum. Characterize and stabilized derived substance. At the heart of the developed technology combined enzymatic methods and membrane technology. 3 An experimental model on which were two songs: a mix factor (plant components) and low molecular weight components of colostrum (CCM) with antitoxic and Immunotropic activity, and can be recommended as new pharmaceutical products. The method have been developed of primary screening of biologically active substances. Prepared recommendations on ways of regulating body functions antitoxic NC plant and animal origin. Patented and developed the foundations of specifications for NC as biologically active substances for the removal of liver fibrosis. The concept of the regulation of body resistance to the toxic effects of copper ions from low antitoxic action of components of biological systems Product Description popup.authors А. Бондар А. Голтвянський К. Лебідь М. Асадова М. Ковальова О. Лінькевич С. Огієнко popup.nrat_date 2020-04-02 Close