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Information × Registration Number 0217U001639, 0114U002409 , R & D reports Title Morphofunctional estimation organotropy and tissue distribution of metal nanoparticles depending on their dispersion and entering ways organism popup.stage_title Head Kundiev Yurij Illich, Registration Date 14-03-2017 Organization State Institution "Institute for Occupational Health of the Academy of Medical Scieces of Ukraine" popup.description2 Objects: nanoparticles (NPs) of sulfide of lead (PbS) 12,5 nm and 100 nm; oxide of iron (Fe2O3) 19 nm and 75 nm, received by method of chemical synthesis; laboratory rats "Vistar" which were exposed to sharp, subsharp and chronic influence of NPs at introduction to a trachea, intraperitoneal, intramuscularly, and also when drawing on the uninjured skin. The colloids of NPs used been standardized on an concentration of chemicals (0,01 M). Work purpose: Morphofunctional estimation organotropy and tissue distribution of metal nanoparticles depending on their dispersion and entering ways organism of experimental rats. Research methods: toxicological, biochemical, chemical analysis, physical and physical and chemical, cytologic, histologic, histochemical, electronic microscopic (TEM, SEM), morphometrical and statistical. Results and their novelty: for the first time on the basis of the complex pilot studies conducted on models of sharp, subsharp and chronic intoxication of rats of NPs of PbS і by Fe2O3 it is established to feature and regularity of their distribution in a liver, kidneys and a myocardium depending on the size, the area of a specific surface and ways of introduction to an organism. It is shown that on processes of absorption, transportation, accumulation and distribution of NPs of metals in target organs also. As well as development of toxic effects is influenced substantially not so much by concentration of chemicals, how many concentration, the size and a way of introduction of NPs to an organism. It is revealed that often low-toxic compounds of iron in case of NPs are capable also itself, as well as NPs of especially toxic metal of lead to get through gemato-tissues barriers, to get to blood, to enter interaction with proteins and blood cells that provides their transportation in target organs, and also distribution and a kumulyation in various structures of a stroma and parenchymal cells. It is shown that NPs of the bigger size are capable to be soaked up in cages, in particular RES by a phagocitos, and more than a NPs small size in parenchymal cells - by an endocitosis that can be Fe2O3 defining in mechanisms of toxic action different in the PbS NPs size і at the cellular and subcellular level. Keywords: Nanoparticles of lead and iron, toxicity, kumulyation and distribution, target organs, morfo-functional changes. Product Description popup.authors Діденко Марія Миколаївна Кундієв Юрій Ілліч Луговський Сергій Павлович popup.nrat_date 2020-04-02 Close