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Information × Registration Number 0217U001746, 0112U008196 , R & D reports Title Molecular and genetic mechanisms of metabolic adaptation and deadaptation to hypoxia influence popup.stage_title Head Portnychenko Alla Georgiivna, Registration Date 26-04-2017 Organization International Center Astronomical, Medical and Ecological Research popup.description2 Report: 118 p., 56 fig., 1 application, 159 references. Object of investigation: development and molecular mechanisms of metabolic adaptation and de-adaptation to hypoxia in rats and humans. Aim: establish the molecular and genetic mechanisms of rebuilding of cell and whole body metabolism under different modes alpine hypoxia during periods of adaptation and deadaptation, to determine the protective effects of hypoxic induction of regulatory genes in metabolic disorders. Methods: physiological, molecular, and biochemical at different levels of structural organization. These investigations allow for the first time characterize the sequence of development of molecular mechanisms during periods of adaptive and deadaptive process, mediated by proteins and transcription factors IGF-1, leptin, apelin, AMPK, SREBP-1 and -2, p53, ApoER2, PON1 in humans and experimental animals, normal and with metabolic disorders (diabetes, metabolic syndrome), and to detect molecular markers of severity of these disorders in people with varying degrees of adaptation to hypoxia, in particular, IGF-1, leptin and PON1. The criteria for applying different hypoxic modes for targeted effects on genes-metabolic regulators, as well as for prevention and treatment of carbohydrate and lipid metabolism disorders by alpine hypoxia and combined hypoxic modes, and the parameters of hypoxic effects to optimize adaptation to high-altitude conditions, treatment and rehabilitation of patients and risk criteria have been determined . As a result of research, the molecular markers for control of metabolic disorders are identified, and clinical recommendations are provided. HIGH ALTITUDE AND COMBINED HYPOXIA, ADAPTATION, DEADAPTATION, EXPRESSION OF PROTEINS - METABOLIC REGULATORS, DIABETES, METABOLIC SYNDROME Product Description popup.authors Василенко Марина Ігорівна Гур'янова Вероніка Леонідівна Лапікова-Бригінська Тетяна Юріївна Портніченко Володимир Ілліч Портніченко Георгій Володимирович Сидоренко Алла Михайлівна popup.nrat_date 2020-04-02 Close