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Information × Registration Number 0217U002343, 0115U001972 , R & D reports Title The generation of novel bioactive osteoplastic materials containig bone morphogenetic proteins for osteogenesis induction. popup.stage_title Head Korchynskyi Olexandr, Registration Date 06-02-2017 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 During the second year of work on the project we have performed in vitro comparison and optimization of ratios for different bone morphogenetic proteins (BMP) while aiming to improve their osteoinductive properties. We have found that BMP preparations generated as a result of cotransfection of 85% of optimized BMP2 and 15% BMP7 plasmids are most efficient inducers of early osteogenesis of mesenchymal precursor cells. Freezing-thawing of BMP2/7 preparations does not reduce their osteoinductive properties. Polyuretan osteoplastic materials were generated as a cooperative effort with Gdansk Polytechnical Univarsity, Gdansk, Poland. These matrices are non-toxic and do not inhibit osteoblast differentiation of mesenchymal precursor cells. Our data will enable a preliminary evaluation of most effective variants of recombinant BMP preparations, primarily BMP2/7 heretodimers, to be used for enhancement of osteoinductive properties of polyuretan-based osteoplastic matrices. Such data will be an important contribution to both deeper understanding of basic molecular mechanisms in BMP signalling and practical use in translational biomedicine amd medical practice. Product Description popup.authors Луцик Максим Дмитрович Стойка Ростислав Степанович popup.nrat_date 2020-04-02 Close