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Information × Registration Number 0217U002795, 0117U002930 , R & D reports Title Synthesis of fluorine containing N,O-heterocyclic structures with various pharmacobiophores based on 1,3-dicarbonyl compounds popup.stage_title Head Sorochinsky A., к.х.н. Registration Date 30-11-2017 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 The reactivity of polyfluoroalkyl-containing derivatives of 2,6,9-trioxabicyclo[3.3.1]nonane and regioselectivity of their reaction with N,N-dinucleophiles was studied. It was shown that the reactions of trifluoromethyl-containing trioxabicyclo[3.3.1]nonanes with hydrazines are general approach to 3,5-di (trifluoromethyl) pyrazoles in 96-98% yield. In reactions with urea derivatives trifluoromethyl-containing trioxabicyclo[3.3.1]nonanes act as a hidden 1,3-dicarbonyl compound and form pyrimidine derivatives containing two trifluoromethyl groups in the 4 and 6 positions with a yield of 94-98%. Bis(trifluoromethyl)containing pyrazoles and pyrimidines are stable for long-term storage due to the presence of strong electron-withdrawing substituents. The structure of the products obtained was established by IR, 1H, 19F, 13C NMR spectroscopy and X-ray diffraction analysis. Product Description popup.authors І.І. Герус К.В. Тарасенко popup.nrat_date 2020-04-02 Close