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Information × Registration Number 0217U002950, 0117U005077 , R & D reports Title Redox modulation of glutathione system in tumor cells with various sensitivities to anticancer drugs popup.stage_title Head Stoika Rostyslav Stepanovych, Registration Date 27-12-2017 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It is shown that selenometionine and D-pantethine partially (by 10-12%), lower cytotoxic effect of doxorubicin towards tumor cell lines in vitro, but at the same time don't affect the level of ROS induced by doxorubicin action. Experiments in vivo on murine NK/Ly lymphoma model showed that the cytoprotective effect of both compounds is explained due to their modulatory action on the glutathione system in target cells. This can significantly reduce side effects of doxorubicin, namely its myelotoxicity and hepatotoxicity. Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close