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Information × Registration Number 0217U002982, 0114U003043 , R & D reports Title Synthesis of new fluoro- and phosphoroorganic reagents for affording of biologically active compounds popup.stage_title Head Gerus Igor, Кандидат хімічних наук Registration Date 28-12-2017 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 The synthetic methods of power synthons, as example, ketophosphonates, diazophosphonates, enones, enaminones and heterocycles with fluorine atoms were developed. New common method of -fluoro- -ketophosphonates, interesting starting material to synthesize analogs of bioactive phosphonates and diazophosphonates, was found by an interaction of various esters of carbonic acids with diethyl fluoromethylhosphonate. First synthesis of new enones with bromomethyl group in -position was performed and the possibility of its using in the reactions with nucleophilic compounds was evaluated. The synthetic power of new ketophosphonates, enones and enaminones was demonstrated for the synthesis of fluorocontaining diazophosphonates and hetero-cyclic systems, such as: pyrazoles, pyridines, pyrimidines etc. Product Description popup.authors І.Б. Кулик І.В. Шевченко І.С. Кондратов В.Г. Долованюк В.Д. Романенко К.В. Тарасенко О.Є. Сорочинський О.М. Федоренко О.М. Хільчевський О.М. Шайтанова С.І. Вдовенко popup.nrat_date 2020-04-02 Close