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Information × Registration Number 0217U002996, 0117U007050 , R & D reports Title Proton-sensitive ion channels as a pharmacological target in the treatment of epilepsy. popup.stage_title Head Maximyuk Oleksandr Petrovych, Registration Date 28-12-2017 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The methods of synthesis of new chemical compounds of carboxamidamide and guanidine series have been developed. 41 candidate compounds have been selected from the library of the KNU by a virtual screening method. 14 compounds were synthesized, including 4 synthesized for the first time. The activity of these compounds on the cells of HEK 293 was investigated by patch-clamp method. The one of the compounds showed activity in the sub-micromolar band. Selected 2 most promising chemotites for further optimization. Product Description popup.authors Єгорова Олена Володимирівна Ісаєв Дмитро Сергійович Волкова Тетяна Михайлівна Кришталь Олег Олександрович Максимюк Олександр Петрович popup.nrat_date 2020-04-02 Close