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Information × Registration Number 0217U003302, 0114U002151 , R & D reports Title To investigate influence of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p-DDD) injection solution on some organs and systems of animal organisms for study of preparation toxity popup.stage_title Head Kravchenko Viktor Ivanovich, Registration Date 28-03-2017 Organization State institution "V.P. Komisarenko Institute of Endocrynology and Metabolism of the National Academy of Medical Science of Ukraine" popup.description2 An aim of work is pre-clinical studies of the toxic effect of the solvent and the solution o, p-DDD (hloditana) in peritoneal administration to rats. The object of study: a solution of 1- (o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dihloretan (o, p-DDD). Research methods: traditional methods of analytical, organic, pharmaceutical chemistry with the use of physical and chemical methods of analysis, histological analysis. The equipment - a set of laboratory glassware, for heating devices, magnetic stirrers. The study found the optimal conditions for producing, p-DDD. The effect of the drug in continuous and pulsed 90-day intraperitoneal injection in general on the organism of experimental animals, and in some organs. In the continuous introduction of solvent and drug o,p-DDD observed toxic effects, primarily due to the action of a solvent. The proposed scheme pulse intraperitoneal injection o, p-DDD (injection for 3 days, a break for two weeks, followed by repetition of the cycle) is less traumatic than continuous. Histological examination revealed that the introduction of the solution in peritoneal o, p-DDD has a specific damaging effect on the cells of the adrenal fascicular zone. Industry applications: medicine. Product Description popup.authors Вакуленко Лідія Іванівна Сімуров Олексій Володимирович Точілкіна Лілія Михайлівна popup.nrat_date 2020-04-02 Close