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Information × Registration Number 0217U003512, 0112U008197 , R & D reports Title Peculiarities of hipometabolic state development at a diabetes by hypoxia popup.stage_title Head Portnichenko Volodymyr Illich, Registration Date 04-05-2017 Organization International Center Astronomical, Medical and Ecological Research popup.description2 Research report: 115 p; 59 image.; 14 table , 78 references; 1 appendix The object of research: mechanisms of adaptation of animals and humans with diabetes to high mountains, carbohydrate metabolism, development hipometabolichnoho state. Aim of research: to establish the physiological, molecular, genetic and biochemical mechanisms of hypomethabolic state during the diabetes on the plains and in the midlemounting. Methods: The functional studies of the external breathing and gas exchange, cardiovascular system and oxygen transport (transthoracic impedance reopletyzmohrafiya, rheoencephalography, rytmocardiografiya, oksyhemometriya), electrophysiological, physiological; polarographic, biochemical, molecular biological, mathematical. It was showed reduce the severity of experimental diabetes in chronic hypoxia inhibition of energy metabolism in the rat liver mitochondria oxidation of NAD-dependent substrates with decreased enzyme activity of complexes I and III and disorganization respiratory electron transport chain. In highland the diabetes mellitus is accompanied with low changes in energy metabolism during oxidation FAD- and NAD-dependent mitochondrial substrates than on the plain. It was found the powerful defense mechanisms associated with hypoxic activation AMRK and apelin in the lungs and the myocardium of rats. In the adapting volunteers from the initial stages of diabetes found favorable impact highlans on the lipid and carbohydrate metabolism. In patients with diabetes highland residents shown the prevalence of hyperkinetic type of circulation. The results justify differences and mechanisms of hypometabolic state on the plain and in the highland. Criteria for therapeutic effects of hypoxia in diabetes elucidated, сlinical recommendations was given. CHRONIC AND ACUTE HYPOXIA HIPOMETABOLICHNYY STATE, DIABETES, BLOOD GLUCOSE, ADAPTATION, CARDIOVASCULAR SYSTEM, MITOCHONDRIA, CHOLESTEROL, AMRK, APELIN. Product Description popup.authors Євтушенко Олексій Левович Іллін Володимир Миколайович Носар Валентина Іванівна Портниченко Алла Георгіївна popup.nrat_date 2020-04-02 Close