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Information × Registration Number 0217U003872, 0115U004731 , R & D reports Title Synthesis of heterocyclic compounds on the basis of N-substituted 1,4-quinoneimines. popup.stage_title Head Авдєєнко Анатолій Петрович, Кандидат хімічних наук Registration Date 28-08-2017 Organization Donbass State Engineering Academy popup.description2 Object of research: unsubstituted and alkyl(halogen)substituted in the quinoid ring N-acyl- and N- [arylsulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinoneimines. Objective of research: to find the rules of the influence of the steric and donor-acceptor properties of the substituents near the nitrogen atom in N-acyl- and N-[arylsulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinonemjnoimines on their reactivity to nucleophiles, and also the synthesis of new heterocyclic potentially bioactive compounds on their basis. Research methods: organic synthesis, physical and chemical methods for the investigation of organic compounds: IR, NMR 1H, NMR 13C spectroscopy, elemental analysis, X-ray diffraction analysis, thin layer and column chromatography. Theoretical and practical results: new heterocyclic compounds on the basis of N-acyl and N-[aryl-sulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinoniminoimines were synthesized. Their structures were proved by the spectral (IR, PMR, NMR 13C) data and elemental analysis. Thiocyanation of N-acyl- and N-[arylsulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinonmonoimines leads to derivatives of 1,3-benzoxazole-2-thione, which are potential bioactive compounds. The revealed laws of reaction ways allow us to predict the place of nucleophilic entry into N-acyl- and N-[arylsulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinonemonoimines. The results of the work extend synthetic possibilities of synthesis of new heterocyclic compounds on the basis of N-substituted 1,4-benzoquinonines. Efficiency of introduction: heterocyclic compounds based on N-acyl- and N-[arylsulfonylimino(methyl, phenyl)methyl]-1,4-benzoquinonmonoimines are potential biologically active compounds and can be used as drugs, pesticides. Application area: in the general and special courses of organic chemistry in classical universities. The products obtained in this work can be tested as new drugs. Product Description popup.authors Авдєєнко Анатолій Петрович Коновалова Світлана Олексіївна Лахтаренко Наталія Василівна Лисенко Олена Миколаївна Марченко Інна Леонідівна Санталова Ганна Олександрівна Холмовой Юрій Петрович Юсіна Ганна Леонідівна popup.nrat_date 2020-04-02 Close