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Information × Registration Number 0217U004123, 0114U003087 , R & D reports Title Study of pathogenetic mechanism in development of gastrointestinal disorders in infants from suffering food intolerance and work out the methods of their diet correction popup.stage_title Head Shadrin Oleg, Доктор медичних наук Registration Date 17-01-2017 Organization State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine" popup.description2 To study the pathogenic mechanisms of gastrointestinal disorders in young children with food intolerances and develop methods of nutritional correction Methods - clinical, biochemical, instrumental, histological, immunological to the analyzer immunosorbent Multiskan Plus, a hydrogen breath test load lactulose was carried out using a gas analyzer Gastro + Gastrolyzer . It is established that the structure of food hypersensitivity infants dominated nealerhichna food intolerance (79.2%). In 40% of patients, according to early age adapted methods of hydrogen breath test and study genotype linked with food intolerance dysaharydaznoyu failure in 60% of children - a prolonged course enterocolitis. For developed methods of hydrogen breath test children with food hypersensitivity syndrome revealed a significant prevalence of bacterial overgrowth in the small intestine and gastrointestinal motility disorders that contribute to the occurrence of the disease. Clinically, food hypersensitivity caused dysaharydaznoyu deficiency syndrome manifests intestinal colic and diarrhea in children in the first six months of life, unlike food allergies and other food intolerance, manifested signs of prolonged enterocolitis. The highest level of sensitization to food allergens found in patients with gastroduodenal lesions. Activity allergic inflammation reflects the concentration of eosinophilic cationic protein that can be used to assess the dynamics of inflammation. A characteristic feature of the inflammatory infiltrate in their own disc of the mucous membranes of the gastrointestinal tract with food hypersensitivity was the presence of eosinophilic infiltration, the most severe in the dysaharydazniy deficiency and food allergies. Activation of macrophage-plazmotsytarnoyi system (expression of CD68, Ig A and Ig E), which reproduces the activation of a local immune response of humoral type. Children with a food intolerance is a violation of the status of the cytokine (TNF ?, IL-5), which correlates with data morfometrychnh research and evidence of inflammatory activity response. High efficiency differential individualized nutrition by medical purpose products and functional foods, combined vegetable enzyme multyprobiotychnyh facilities and complexes. Product Description popup.authors Арчакова Т.М. Басараба Н.М Бондаренко Н.Ю. Дюкарєва С.В. Задорожна Т. А. Коваленко Г.Б. Ковальчук А.А. Місник В.П Марушко Т.Л. Радушинська Т.Ю. Хомутовська К.О Шадрін О.Г popup.nrat_date 2020-04-02 Close