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Information × Registration Number 0217U004126, 0111U007699 , R & D reports Title To elaborate complex preparations on the izatizon basis and to study their antiviral and antitumor action popup.stage_title Head Potopalsky Anatoly Ivanovich; Zaika Leonid A., Registration Date 17-01-2017 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The object of study - antiviral, anticancer and immunomodulatory drugs in appropriate models. The purpose of research - to study the antiviral drug isatizone and based on it nanocomplexes and drugs with immunomodulatory effects. Results - isatizone complexes are created and such their properties has been studied as: physico-chemical properties, cytotoxicity, anti-viral, anti-tumor and immunomodulatory activities. High antiviral activity of complexes has been proved on models of herpes virus infections in vitro and in vivo and on surrogate model of hepatitis C virus human (in vitro), that was confirmed by PCR (real-time).. Isatizone and its complexes can induce apoptosis in malignant cells by activating caspase-3, which can be either external or internal means. Experimentally proved the effectiveness of the integrated application of xenogeneic tumor vaccine and isatizone as antitumor agents. There is the greatest life span in animals with experimental tumors and the lowest level of metastatic lung lesions. Administration of drugs leads to increasing of G class antibodies in the serum of animals with Lewis lung carcinoma. Isatizone with vaccine inhibit metastasis by suppressing the expression of TGF-b1, VEGF-a, IL-17a genes. Cellulose based nanocomposite are designed for isatizone transdermal delivery in treatment of wounds, burns, bedsores, etc.). The value of the work- the prospects of further experimental and clinical studies of these drugs has been shown. Product Description popup.authors Болсунова Ольга Ігорівна Заєць Ірина Євгеніївна Задорожній Борис Олексійович Кацан Валентина Андріївна Козировська Натілія Олексіївна Кухаренко Ольга Євгеніївна Орловська Ірина Володимирівна Подоліч Ольга Віталіївна popup.nrat_date 2020-04-02 Close