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Information × Registration Number 0217U004136, 0115U003347 , R & D reports Title The influence of the nervous system in animals of different ages on the immune and antioxidant systems of the organism and their correction popup.stage_title Head Valentin Karpovskiy, Registration Date 17-01-2017 Organization National university of Life and Environmental Sciences of Ukraine popup.description2 Object of study is the cortical-autonomic regulation of antioxidant and immune systems in the body of pigs. The aim of the study is to development of new methods applied correction antioxidant and immune protection of animals by studying its formation from birth to maturity and physiological effects on neural regulation of these processes. Methods of study is the physiology (study of higher nervous activity and tone of the autonomic nervous system of pigs), hematology (the study of hemoglobin, red blood cell and white blood cell count pigs), immunology (study of bactericidal and lizotsym activity of blood serum, the phagocytic activity of neutrophils and number of circulating immune complexes blood pigs), biochemical (research performance antioxidant body), statistics (determination of average values and their errors of probability, correlation, single-factor variance and regression analysis). It is established that the activity of enzymatic antioxidant defense system in erythrocytes of pigs weak type of higher nervous activity is at a much lower level than the animals severe types of higher nervous activity during the period of research. Intensification of lipid peroxidation at weaning reduces the activity level of antioxidant hlutationovoyi animals of all types of higher nervous activity. Animals weak type of higher nervous activity established glutathiones low activity level of antioxidant protection, indicating that the low adaptive capacity and stress of animals. Set basic properties of cortical correlation processes and the tone of the autonomic nervous system of indicators to immunological reactivity and technological stimulus for action: the closest relationship regarding the strength and balance of excitation and inhibition in the cortex of the brain, which confirmed the expectation indicators potency. Connections vary both majestic and depending on the direction of the impact of technological stimulus. These data suggest regrouping cortico-vegetative regulatory mechanisms of adaptation of pigs in terms of technological stress factor that deepens existing knowledge about individual mechanisms regulating immune responses in pigs. Developed and experimentally established optimal dose of nanocomplex vitamin E (micellar form of encapsulated ?-tokoferol acetate). Adding to the diet of animals 180 ml micellar solution of vitamin E (vitamin E concentration of 0.25 kg/m3 at a dose of 2 ml / kg) for 30 days enhances the concentration of vitamin E in blood plasma at 22.38% (p <0.05) compared with the control group sows, which is 11.04% more than in sows treated with alcoholic solution of vitamin E. The proposed micellar system with encapsulated vitamin E has a probable impact force to the content of lipid peroxidation products as a result of which the red blood cells reduced the content of diene conjugates and Schiff bases. Application of the results is possible in the field of veterinary medicine, agriculture and stockbreeding.5481 Product Description popup.authors Василів Андрій Петрович Гудзь Тетяна Анатоліївна Данчук Олексій Володимирович Журенко Олена Василівна Карповський Валентин Валентинович Карповський Павло Валентинович Кладницька Лариса Володимирівна Кравченко-Довгач Юлія Володимирівна Криворучко Дмитро Іванович Ландаренко Людмила Сергіївна Ландсман Альона Олександрівна Постой Руслана Вікторівна Саулко Вячеслав Володимирович Скрипкіна Віта Миколаївна Трокоз Віктор Олександрович popup.nrat_date 2020-04-02 Close