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Information × Registration Number 0217U004338, 0114U002847 , R & D reports Title Investigation of spontaneous and radiation induced chromosomal instability in peripheral blood lymphocytes of all ages persons popup.stage_title Head Pilinskaya Maria Andriivna, Доктор медичних наук Registration Date 31-01-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object: human peripheral blood lymphocytes. Objective: establish spontaneous and induced by radiation cytogenetic effects and the level of chromosomal instability due bystander effect in peripheral blood lymphocytes of people of all ages. Methods: Cytogenetic. Results: Spontaneous and induced by radiation (dose of 0.25 Gy) cytogenetic effects in vitro in peripheral blood lymphocytes of individuals aged 12 to 102 years old lived in Kyiv were observed. Chromosomal instability and radiosensitivity increased in 60-70 years old people. The greatest number of radiation-indused damages were detected in chromosomal bands 1q32, 2q31, 5q31, 8q22, 11q23 and 18q21 where genes of reparation proteins (C3DR and VWS, PMS1 and WSS, RAD50, NBS1, ATM, POL1) are located. After cocultiations irradiated and nonirradiated lymphocytes radiation-induced bystander effect was registered in nonirradiated cells of adolescents, middle aged and elderly persons, but not in cells of long-livers. Fields of use: radiation genetics. Product Description popup.authors Демченко Олена Миколаївна Курінний Денис Аркадійович Пілінська Марія Андріївна Талан Оксана Олексіївна Шеметун Олена Володимирівна popup.nrat_date 2020-04-02 Close