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Information × Registration Number 0217U004341, 0115U002696 , R & D reports Title Research of the spectrum and the frequency of chromosome aberrations and the parameters of DNA methylation in peripheral blood lymphocytes of healthy volunteers after irradiation in vitro for G0 and G2-phases of the mitotic cycle popup.stage_title Head Pilinskaya Maria Andriivna, Доктор медичних наук Registration Date 31-01-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object : peripheral blood lymphocytes.Aim: set the frequency of different types chromosoms aberrations in peripheral blood lymphocytes of healthy volunteers after exposed to irradiation in vitro in the G0 and the G2-phases of the mitotic cycle, and possible changes of parameters DNA methylation. Methods: Cytogenetic, molecular genetic. Results: established increase radiogenic cytogenetic markers - dicentric and centric rings in the G0 phase, and single fragments and chromatid exchanges in the G2 phase of the cell cycle. The change in frequency of DNA damage of parameters in lymphocytes in vitro after irradiation at a dose of 1.0 Gy to the G0 and G2 phases of the mitotic cycle was defined . The change in the level of global methylation of DNA defined after irradiation in peripheral blood lymphocytes of healthy volunteers. Fields of use: radiation genetics. Product Description popup.authors Єрємеева Марія Миколаївна Дибська Олена Борисівна Курінний Денис Аркадійович. Пілінська Марія Андріївна Степанова Людмила Сергіївна popup.nrat_date 2020-04-02 Close