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Information × Registration Number 0217U004342, 0115U002697 , R & D reports Title Experimental and clinical determination of the effect of prenatal exposure iodine-131 on neurogenesis and cognitive development, and emotional and mental disorders. popup.stage_title Head Tal'ko Viktoriya Vasylivna; Loganovskiy Kostiantyn Mykolayovych, Registration Date 31-01-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object: neuroradiobiological effects in the body prenatally exposed iodine-131 rats Wistar. State of the nervous system and psyche 104 exposed in utero as a result of the exposed and 78 unexposed persons in utero. The aim: to investigate the role of radiation breach of neurogenesis in the pathogenesis of neuropsychiatric effects of exposure iodine-131 brain develops. to investigate changes in neurogenesis in the brain under the influence of exogenous factors as the basis for the development of innovative methods of rehabilitation of patients with traumatic lesions of the central nervous system. Мethods of experimental research - behavioral, ELISA, biochemical, morphological, statistics. Мethods of clinical research - clinical neuropsychiatric, and neuro-psychometric, neuropsychological, neurophysiological, statistics. Results. Comparative evaluation of experimental and clinical work confirms radioneuroembryological radiosusceptibility central nervous system to the action of even low doses of ionizing radiation, including iodine-131. Clinical studies in utero exposed to contaminated areas of the Chernobyl accident, compared with corresponding doses of iodine-131 experiment indicate the presence of cognitive deficits and emotional and behavioral disorders due to breach cortical-hipokampal neurogenesis due to radiation including iodine-131. In utero exposed individuals stored characteristic cognitive deficit that is disharmony intellectual development due to the relative decrease in verbal intelligence compared to the relative growth of non-verbal intelligence, which may indicate dysfunction of the cortico-limbic system, the hippocampus is particularly dominant hemisphere. Reducing the spectral power theta - range (4-7 Hz) brain activity in the left frontal- temporal region in utero exposed individuals show hipokampal dysfunction, mainly in the dominant hemisphere. Product Description popup.authors Дмитрієва І.Р. Логановська Т.К. Прохорова Є.М. Тукаленко Є.В. popup.nrat_date 2020-04-02 Close