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Information × Registration Number 0217U004776, 0114U000698 , R & D reports Title Development of high-efficiency methods of management of pharmaceutical substances dispersion by means of microwave radiation and ultrasound for further creation of new medicinal preparations with high therapeutic activity. popup.stage_title Head Chebanov Valentin Anatolievich, Registration Date 02-03-2017 Organization State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine popup.description2 The efficiency of different micronization techniques of acyclovir, nefopam and meloxycam has been studied. The advantages of ultrasound in the liquid-phase micronization over mechanical milling of the substances have been demonstrated. At the same time the cooling crystallization with ultrasound-induced nucleation was shown to significantly improve the micronization efficiency. Higher release speed and therapeutic activities of the micronized Nefopam was shown in in vitro and in vivo studies respectively. The effect of the particle size on the substance distribution in a suppository mass was studied. The storage stability tests have been performed on the medicinal products prepared with the use of the micronized substances. Product Description popup.authors Безугла О.П. Волошко О.Ю. Ляпунов М.О. Пінчукова Н.О. Чебанов В. А. popup.nrat_date 2020-04-02 Close