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Information × Registration Number 0217U004786, 0116U002408 , R & D reports Title To develop the bioengineering technology of magnetic nanotheranostics of malignant tumors. popup.stage_title Head Orel Valery Emmanuilovich, Доктор біологічних наук Registration Date 03-03-2017 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The object of study: magneto-sensitive complex of Fe3O4 nanoparticles and doxorubicin; blood serum, the localizer; cell lines: T47D human breast cancer and A-549 human small cell lung cancer; rats with Guerin carcinoma. Equipment: mechano-magneto-chemical reactor; apparatus for local shortwave inductothermy "Magnitherm" (Radmir, Ukraine); MRI Signa Ovation (General Electric). The purpose of work: to develop the concept of bioengineering technology of magnetic nanotheranostics of malignant tumors based on the combined use of magneto-sensitive nanocomplexes as therapeutic anticancer agent and X-ray diagnostics contrast agent. Research methods: physical, technical, physico-chemical, cytological, laboratory and statistical. The unit for the study of the effect of electromagnetic radiation on the electrical resistance of blood serum of cancer patients with anti-tumor magneto-sensitive nanocomplex was designed and manufactured. The experimental evidence was obtained that electromagnetic waves can change the electrical resistance of Fe3O4 nanoparticles and surrounding molecules of antitumor drug doxorubicin in the blood serum. The difference between the influence of iron oxide nanoparticles and Fe2+ iron ions on the electric resistance in the blood serum was shown. In experiments in vitro the differences in viability of T-47D human breast cancer cells and A-549 non-small cell human lung cancer cells under the influence of magneto-sensitive nanocomplex and electromagnetic irradiation and doxorubicin were identified. The changes in viability percentage of cancer cells for A-549 human lung cancer and T-47D human breast cancer have been non-linearly depending on the magnetic moment of nanocomplex. An algorithm of magnetic nanotheranostics of malignant tumors which combines MRI diagnostics and magnetic nanotherapy involving magnetic nanoparticles as active agents was developed. In the future, it could be used for further preclinical studies in vivo and next implementation into clinical practice. Product Description popup.authors Дзятковська Ірина Ігорівна Романов Андрій Вікторович popup.nrat_date 2020-04-02 Close