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Information × Registration Number 0217U004915, 0113U007275 , R & D reports Title Cell and molecular mechanisms of the brain neurons functioning in norm and pathology popup.stage_title Head Marchenko Sergiy Myhailovych, Registration Date 28-11-2017 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Shown that the natural alkaloid tubocurarine is a selective blocker of large-conductance channels of nuclear membrane of Purkinje neurons. Also shown that inhemi-parkinsonic rats the qualitative and quantitative kit of ion channelson the inner nuclear membrane of neurons in different brain structureswaschanged, that can lead to the modulationof calcium signaling.Moreover, was shownthat the blockade of the nNOSsystem in the brain enhances the c-Fos expression in neurons of the nucleus proprius and motor nuclei in the spinal cord of rats realized operant movements,because of disinhibition of segmental interneurons and motoneurons. New data about the tubocurarine, as the first known selective blocker of large-conductance channels of nuclear membrane of neurons, open perspectives to clarify the physiological role of these channels. New data about changes in calcium signaling in neurons during experimental parkinsonismare very important to find the methods of pharmacological correction of motor disorders in neurodegenerative diseases.5481 Product Description popup.authors Бобришев Андрій Юрійович Котлярова Анна Борисівна Лунько Олеся Володимирівна Майський В. О. Маньківська О. П. Марченко Сергій Михайлович Поліщук Анна Олександрівна Розумна Н. М. С.М.Мамонтов Федоренко Олена Андріївна popup.nrat_date 2020-04-02 Close