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Information × Registration Number 0217U004920, 0114U007233 , R & D reports Title Investigation of mechanisms of myocardial remodeling in the pathogenesis of heart failure and its correction popup.stage_title Head Dosenko Viktor Yevgeniyovych, Registration Date 28-11-2017 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 As a result of studies it was found that the use of an autophagy blocker for chloroquine in aging leads to an improvement in cardiohemodynamic parameters in SHR rats. Also, a decrease in fibrotic changes in the left ventricle and a decrease in the development of oxidative stress in SHR rats by the action of chloroquine were revealed. A low level of mature microRNA-1 and a high level of primary and precursor microRNA-1 in SHR rats were established during aging. Also, a decrease in the expression of SUR1 and SUR2 regulatory subunits of ATP-sensitive potassium channels in old SHR animals was detected. It has been shown that the use of wortmanin reduces the number of neutrophil extracellular traps and increases the number of live cardiomircites.5481 Product Description popup.authors А.М.Шиш А.С. Жуковська В.Є.Досенко В.Л. Гур'янова В.С.Нагібін Г.В. Портніченко Д.О. Строй Д.О.Пашевін Л.В.Тумановська О.В. Сваричевський О.С. Панасюк Р.А. Ровенець Р.Б.Струтинський С.В. Гончаров popup.nrat_date 2020-04-02 Close