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Information × Registration Number 0217U004956, 0115U006646 , R & D reports Title Treatment and prevention of socially important non-infection diseases of the cardiovascular system and the musculoskeletal system through a systemic analysis of the risk factor. popup.stage_title Head Yakimenko Elena Alexandrovna, Доктор медичних наук Registration Date 05-12-2017 Organization Odesa National Medical University popup.description2 The subject of the study is a clinical picture, the distribution of genes in 515 patients with coronary heart disease, hypertensive disease, dyslipidemia, osteoarthrosis of knee in metabolic syndrome. The aim of the work is to study the genetic features of hypertensive disease, coronary heart disease, osteoarthritis in the metabolic syndrome and their association with clinical manifestations of comorbid pathology. The association of genetic markers with the features of the clinical course, namely: alleles of NO and eNOS genes - with the parameters of endothelial dysfunction and stenting efficiency in patients with IHD, features of cardiac remodeling of coronary hypertensive disease is observed in patients with hypertension, IHD, dyslipidemia, osteoarthritis and metabolic syndrome ; alleles of the SLCO1B * 5 gene with the efficacy and safety of rosuvastatin therapy for dyslipidemia; alleles of the genes Сol1А, VDR, IL1А1, ER: Хbаl - with pain syndrome, intensity of inflammation in the knee joints, progression of articular cartilage damage in osteoarthritis. Product Description popup.authors popup.nrat_date 2020-04-02 Close