Search academic texts

Information × Registration Number 0217U004971, 0116U008927 , R & D reports Title To create and substanciate the methods of fibrous changes correction in case of chronic hepatitis and hepatic cirrhosis popup.stage_title Head Kholodkova Olena Leonidivna, Registration Date 05-12-2017 Organization Odesa National Medical University popup.description2 As a result of the conducted studies, we obtained data on the morpho-functional status of the liver and the system of cytokines in experimental chronic hepatitis and liver cirrhosis. It has been determined that the formation of chronic hepatitis has certain stages of morphological and biochemical changes. Significant fluctuations during the simulation of the pathological process also experience a balance of pro- and anti-inflammatory cytokines. In the liver there are changes in the ultrastructural organization of hepatocytes and the vascular component of the organ; growth of relative area of connective tissue due to parenchyma. In cirrhosis of the liver, along with a violation of the functional parameters of the liver, there is significant fibrosis of portal tract with the accumulation of long collagen fibers and a significant increase in the content of proinflammatory cytokines. Product Description popup.authors Антонова Наталія Анатолііївна Горчаг Денис Михайлович Кожухаренко Тетяна Іванівна Колесниченко Олена Анатоліївна Нескоромна Наталія Владиславівна Перепелюк Микола Миколайович Прус Руслан Володимирович Ромак Олег Ігорович Холодкова Олена Леонідівна Чеботарьова Світлана Олегівна popup.nrat_date 2020-04-02 Close