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Registration Number

0217U006004, 0114U003012 , R & D reports

Title

Explore the patterns of development of compartment syndrome and its effects and perfoming system of diagnosis and treatment (experimental clinical research)

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Head

Strafun Serhii Semenovich, Доктор медичних наук

Registration Date

24-01-2017

Organization

Ukrainian scientific-research institute for traumatology and orthopaedics

Description

The study discovers new links in pathogenesis of the formation of ischemic limb contractures. In particular, it was experimentally proved that in ischemia there is a close feedback between the fascial compartment pressure and intraosseous pressure, which shows direct relationship between the blood supply of bone and the blood circulation of its surrounding muscle tissue. It was established that under the fascial compartment pressure over 50 mm Hg the intraosseous pressure drops to 0. It was established that in development of the regional blood supply deficiency pathomorphologic alterations of vessels and nerves of the damaged limb, particularly from the side of microvasculature that suffers in the limb traumas first of all are of the fundamental importance. This is the fist study in Ukraine where the possibilities of muscular fiber contraction under conditions of an acute ischemia were studied. Specific signs of the ischemic muscles are tremor and impossibility of theforming the motor pattern. For the first time in Ukraine classification of the hand ischemic contracture was developed thereby making it possible to improve diagnostic procedures, thus promoting proper treatment of patients belonging to this category. Significant probable strong positive relationship between the severity of compartment syndrome and percentage of necrosis of the ischemic muscle was found. Significant probable negative relationship was established between the percentage of necrosis and vertical ?-entropy of ischemic muscles , i.e. the higher is necrosis %, the less are the structural properties of the nearby muscular tissue. In correlation with horizontal ?-entropy an analogous relationship of the medium power was noted. The basic characteristics of the total (subtotal), ischemic damage and irreversible changes of muscles were revealed: destructibility of the larger part and abundance of the muscular area, multiple loci of the “total bioelectric silence”, absence of areas with normal introduction amplitude at the tree levels of myogaster. System of the reconstructive and recovery treatment of patients with ischemic contracture depending on its duration period and severity degree as well as on the concomitant injuries was developed. The use of such approach made it possible to improve the function of ischemic foot by 2.5 times and the function of ischemic hand by 14%.with high degree of significance (р < 0.01, р < 0.05)

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Батанова Ніна Юхимівна
Безуглий Артур Анатолійович
Боєр Володимир Альфредович
Гайович Ігор Володимирович
Гайович Василь Васильович
Григоровський Валерій Володимирович
Долгополов Олексій Вікторович
Курінний Ігор Миколайович
Лєсков Володимир Григорович
Половинка Лідія Олексіївна
Страфун Олександр Сергійович
Страфун Сергій Семенович
Тимошенко Сергій Вікторович