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Information × Registration Number 0217U006096, 0115U001049 , R & D reports Title To study clinical -pathogenic and neurobiological mechanisms of impairments of the sleep - wake cycle and its correction in patients with different types of course of multiple sclerosis popup.stage_title Head Voloshyna N.P., Sukhorukov V.I., Registration Date 09-02-2017 Organization Ukrainian SRI of Clinical and Experimental Neurology and Psychiatry popup.description2 Object of investigation: 38 patients with multiple sclerosis. Aim of the SRW: to study clinical-neurological, neurobiological mechanisms of impairments of the sleep-wake cycle and its correction in patients with different types of course of multiple sclerosis. Methods of investigation: clinical-neurological, neuropsychological, biochemical, statistical, methods of questionnaires and polysomnography. Results: A heterogenic character and multifactorial pathogenesis of impairments of the sleep-wake cycle were defined in patients with different types of course of multiple sclerosis. It was found out that demyelinating and degenerative brain damages resulted in brain dysfunction and disintegration of neurotransmitter systems regulating the sleep-wake cycle. Signs of impairments of non-specific brain systems were defined. It was determined a biochemical marker of prognosis for progredient types of course of multiple sclerosis. Product Description popup.authors І. Розщупкіна А. Тіткова В. Василовський В. Сухоруков Г. Перцев К. Пісоцька Л. Забродіна Л. Мішина Л. Терещенко М. Черненко Н. Давиденко Н. Петрухіна Н. Привалова П. Мартишко Р. Єна Т. Негреба popup.nrat_date 2020-04-02 Close