Search academic texts

Information × Registration Number 0217U006185, 0114U000247 , R & D reports Title Experiental rationale for developing drugs with antimicrobial effect of Humulus lupulus products for the prevention and treatment of inflammatory diseases of the oral cavity popup.stage_title Head Kazmirchuk Victor Vоlоdуmirovуch, Registration Date 27-02-2017 Organization The Mechnikov Research Institute of microbiology and immunology at Kharciv popup.description2 Experimentally iuzucheno antimicrobial activity of Humulus lupulus products and substances as an active ingredient selected Humulus lupulus extract carbon dioxide as the most active. As a result of studies of the effect of excipients on the antimicrobial activity of Humulus lupulus extract carbon dioxide vibrat polietilenoksid 400, propyleneglycol, and developed an optimal composition of the new drug. It proved a high antimicrobial activity against a gel museum gram (S.aureus, S. pneumoniae, S. epidermidis, S. haemolitikus) lower with respect to Gram-negative (E. coli, P. aeruginosa) clinical strains of microorganisms and microorganisms (S. aureus, S. mutans, N. rerflava, Acinetobacter, E. faecalis, etc.). In relation to the genus Candida fungi most of observed high fungistatic action. Studied the physical and physicochemical properties of a gel with a carbon dioxide Humulus lupulus extract and proved stability of the gel is elaborated quality characteristics (description, pH, viscosity, homogeneity), and antimicrobial activity, have been studied over the period of study. According to the results of pharmacological studies determined that the drug developed with carbon dioxide Humulus lupulus extract refers to a class IV toxicity is low toxic, safe and has antiinflammatory effect. Results of research will be used to create a new drug with a carbon dioxide extract of Humulus lupulus for the prevention and treatment of inflammatory diseases of the oral cavity. Product Description popup.authors Волянська Н. О. Довга І. М. Казмірчук В. В. Поволокіна І. В. Шульга Н. М. popup.nrat_date 2020-04-02 Close