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Information × Registration Number 0217U006346, 0114U001384 , R & D reports Title To develop new diagnostic and therapeutic measures for spread dermatomycoses of skin and its appendages popup.stage_title Head Kutasevych Yanina Francivna, Registration Date 29-03-2017 Organization Ukranian research institute of dermatology and venerology popup.description2 Object of study: dermatomycoses of the skin and its appendages. The aim was to increase the efficiency of early diagnosis of fungal infections of the skin and its appendages and optimization of therapeutic and prophylactic methods to prevent these diseases. Methods: Clinical, biochemical, molecular, mycological, epiluminescence diagnostics (dermatoscopy of nail plate), bacteriological, statistics. According to dermatoscopic features of onychomycosis index of defeat of nail plates was developed. The algorithm for the diagnosis of onychomycosis involving epiluminescence microscopy and polymerase chain reaction that increases the sensitivity of pathogen detection methods to 91.9% diagnostic accuracy - up to 90.3% and significantly reduces the time of diagnosis proposed. Proved that the polymerase chain reaction is a method of diagnosis that helps to identify atypical forms of dermatomycoses. The complex treatment of patients with onychomycosis involving antifungal agents and tools that improve the structure of the nail plate and to accelerate the regrowth that reduces treatment time and reduces the risk of side effects was designed. The study of the state of biochemical parameters of liver function were found signs of cytolytic syndrome, normalized in the complex treatment with detoxification facilities. In the treatment of dermatomycoses There was normalization of elevated levels of spontaneous peroxidation and erythrocyte osmotic hemolysis. During bacteriological study of patients with treatment of dermatomycoses strains with high pathogenic properties and high contamination was detected. After the comprehensive treatment tended to normalize skin lesions in biota. The data show that the use of liposomal antimycotics is more effective on C. albicans fungi and indicate the possibility of their use in the treatment of cutaneous forms dermatomycoses. Proved that topical terbinafine is fungicidal activity against a variety of cultures Trichophyton mentagrophytes var gypseum and Microsporum canis, in the treatment of trychomicoses reached 100% elimination of fungi end of the third week of therapy. Product Description popup.authors Іванова Ніна Миколаївна Білозоров Олексій Павлович Безрученко Ізаїта Антонівна Джораєва Світлана Кар'ягдиївна Земляна Тетяна Вікторівна Кондакова Ганна Костянтинівна Кутасевич Яніна Францівна Левицька Олена Володимирівна Мілютіна Олена Йосипівна Матюшенко Валерія Павлівна Маштакова Ірина Олексіївна Олійник Ірина Олександрівна П'ятикоп Інна Олександрівна Семко Галина Олександрівна Сокол Оксана Анатоліївна Стулій Ольга Миколаївна Супрун Ксенія Григорівна Цимбал Вікторія Миколаївна Частій Тетяна Володимирівна Юхимчук Євгеній Володимирович popup.nrat_date 2020-04-02 Close