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Information × Registration Number 0217U006610, 0116U004319 , R & D reports Title The mechanisms of neurohormonale and immune violations at brain traumatic injury and the ways of its pathogenetic correction. popup.stage_title Head Krishtal N. V., Registration Date 13-07-2016 Organization National Medical University by Bogomolets popup.description2 Purpose: to establish mechanisms for the formation of immunodeficiency and autoimmune syndromes in traumatic brain injury on the basis of an analysis of the indices of inflammatory, immune and autoimmune reactions; determine the pathogenetic role and the main indicators of the development of the revealed violations. Methods: modeling of trauma (247 male rats weighing 190 g to 210 g at the age of 6-8 months, who modeled the traumatic brain injury by free falling of the load on the fixed head of the animal, the control group consisted of 25 false-injured animals), the definition of the neurological deficits; immunological, biochemical, morphological and immuno-histochemical, statistical. The received results: unmasking of neuronal antigens (S100B, NSE and GFAP) as a result of the violation of the hemato-encephalic barrier in trauma triggered further (secondary) activation of glial, lymphocytic and macrophagic reactions in the brain tissues. Parallel secondary activation of the systemic inflammatory response, activation of the interleukin cascade, systemic intoxication serve as a sensitizing background, which enhances secondary damage to the brain tissue and switches the immune response from cellular (T-cell immunodepression) to humoral (humoral hyperreactivity) types. The critical period in the development of these reactions is the seventh day after the injury, when secondary inflammatory reactions and signs of autoimmune damage appear in the form of specific antineuronal antibodies and diffuse macrophage infiltration of brain tissue Product Description popup.authors Грішов А.А. Зябліцев С.В. Кришталь М.В. Мироненко О.І. Стародубська О.О. Фокіна Д.О. popup.nrat_date 2020-04-02 Close