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Information × Registration Number 0217U006890, 0116U004294 , R & D reports Title Application of functional nanomaterials for creation of biosensor conductometric devices for arginine detection: molecular design and chemical synthesis of calixarenes able to formation of cooperative electrostatic interactions and hydrogen bonds with arginine. popup.stage_title Head Cherenok Serhii Olexiyovich, Registration Date 21-12-2017 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 The objects of the study are new calix[4]arenephosphonic acids with alkylthiol anchor groups on the lower rim of the macrocycle. Accordingly, the aim of the work is elaboration the available methods for the synthesis of calixarenephosphonic acids containing anchor alkyl sulfide substituents on the lower rim of the macrocycle, and the obtaining on their basis the sensitive elements of conductometric devices - sensors for arginine. Methods have been developed for the synthesis of cone-shaped calix[4]arenes containing fragments of methylphosphonic acid or methylenebisphosphonic acid on the upper rim of the macrocycle, capable of forming supramolecular complexes with amino acids. Simultaneously, on the lower rim of the macrocycle, these calixarene-methylphosphonic and -methylenebisphosphonic acids contain anchor alkyl sulfide substituents capable to chemical binding with microchips of conductometric sensors whose surface is covered with gold. Complexation with amino acids of different nature was investigated by HPLC and molecular modeling methods and the stability constants of inclusion complexes with amino acids were determined. Product Description popup.authors Єсипенко Олександр Адольфович Атамась Людмила Іванівна Вишневський Сергій Григорович Денисенко Ольга Миколаївна Довгоп'ята Лідія Соловеївна Допіра Тетяна Іванівна Драпайло Андрій Богданович Кальченко Віталій Іванович Лісова Ганна Олексіївна Осіпова Анастасія Олександрівна Приньова Олена Станіславівна Родік Роман Васильович Сіленко Олег Миколайович Святненко Ганна Степанівна Черенок Сергій Олексійович Ярош Олександр Кузмич popup.nrat_date 2020-04-02 Close