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Information × Registration Number 0217U006903, 0115U005687 , R & D reports Title Role of MRPS18-2 protein in regulation of cell cycle and cancerogenesis popup.stage_title Head Kashuba Olena Vitaliivna, Доктор біологічних наук Registration Date 22-12-2017 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 During the project implementation, open databases were analyzed and it was shown that protein R18 protein S18-2 is expressed at very low levels in retinoblastoma and osteosarcoma when the expression of RB protein is lost. It has been shown that the simultaneous exposure of the S18-2 and RB proteins of the Saos-2 osteosarcoma cell line and the Weri-RB retinoblastomas is transformed. RB1-knockout embryonic fibroblasts of mice are transformed into immortalized cells that have a phenotype characteristic of stem cells. Immortalized cells can be differentiated in culture using cocktails of chemicals, and also show elevated telomerase activity. Moreover, the administration of high concentrations of S18-2 protein into tumor cells leads to the death of malignant cells. Product Description popup.authors Бреєва Ольга Володимирівна Бучинська Любов Георгіївна Глущенко Надія Миколаївна Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна Несіна Ірина Петрівна Юрченко Наталя Петрівна popup.nrat_date 2020-04-02 Close