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Information × Registration Number 0217U006931, 0115U002970 , R & D reports Title Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy popup.stage_title Head Sidorenko Svitlana Pavlivna, Доктор біологічних наук Registration Date 27-12-2017 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We created molecular genetic constructs that encode glutathione-S-transferase (GST) chimeric proteins in the cytoplasmic domains of nCD150 or mCD150 isoforms. The partner proteins mCD150 isoforms were identified (interactive): the non-phosphorylated GST-mCD150 was bound with the SH2D1A (SAP) adapter protein and serine / threonine kinase HPC1; phosphorylated for tyrosine GST-mCD150pY precipitates SH2D1A (SAP), tyrosine phosphatase SHP-2, inositol phosphatase SHIP and p85 regulatory subunit of PI3-kinase. The biological features of model cell lines with the expression of mCD150 and nCD150 isoforms have been revealed. Product Description popup.authors Гордієнко Інна Михайлівна Ковалевська Лариса Миколаївна Сидоренко Світлана Павлівна Холоднюк Валерія Михайлівна Шлапацька Лариса Миколаївна popup.nrat_date 2020-04-02 Close
R & D report
Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy
Head: Sidorenko Svitlana Pavlivna. Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy. (popup.stage: ). R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology. № 0217U006931
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Updated: 2026-03-25


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