1 documents found
Registration Number

0217U006931, 0115U002970 , R & D reports

Title

Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy

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Head

Sidorenko Svitlana Pavlivna, Доктор біологічних наук

Registration Date

27-12-2017

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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We created molecular genetic constructs that encode glutathione-S-transferase (GST) chimeric proteins in the cytoplasmic domains of nCD150 or mCD150 isoforms. The partner proteins mCD150 isoforms were identified (interactive): the non-phosphorylated GST-mCD150 was bound with the SH2D1A (SAP) adapter protein and serine / threonine kinase HPC1; phosphorylated for tyrosine GST-mCD150pY precipitates SH2D1A (SAP), tyrosine phosphatase SHP-2, inositol phosphatase SHIP and p85 regulatory subunit of PI3-kinase. The biological features of model cell lines with the expression of mCD150 and nCD150 isoforms have been revealed.

Product Description

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Гордієнко Інна Михайлівна
Ковалевська Лариса Миколаївна
Сидоренко Світлана Павлівна
Холоднюк Валерія Михайлівна
Шлапацька Лариса Миколаївна

R & D report
Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy
Head: Sidorenko Svitlana Pavlivna. Experimental justification of CD150 isoforms application as potential diagnostic markers and targets for directed anti-tumor therapy. (popup.stage: ). R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology. № 0217U006931
1 documents found

Updated: 2024-12-22


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