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Information × Registration Number 0217U007275, 0117U007009 , R & D reports Title Structural theory of the spontaneous point mutagenesis popup.stage_title Head Brovarets' Ol'ha Oleksandrivna, Registration Date 22-12-2017 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 At the MP2/cc-pVQZ//B3LYP/6-311++G(d,p) level of theory it was investigated the most obscure questions concerning the nature of the occurrence of errors in DNA, namely: the Т*О2 tautomer forms incorrect hydrogen-bonded pairs with A, G, C and T, which, in turn, can acquire enzymatically-competent sizes, that is, it is an active participant in the mutagenic events at the molecular level; the rotation of the hydroxyl and imino groups of mutagenic tautomers of the DNA base at an angle of 180 degrees does not deactivate their activity; complete sets of incorrect pairs of DNA bases that determine both incorporation and replication errors are determined, and their completness has been proved; it was found that the incorrect purine-purine pairs are common intermediates on the way of the obtaining of the enzymatically-competent conformation; it was described in details the structural scenario of the origin of each of the 12 possible point incorporation and replication errors, that is, the molecular logic of spontaneous point mutagenesis. Product Description popup.authors Броварець Ольга Олександрівна Говорун Дмитро Миколайович popup.nrat_date 2020-04-02 Close