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Information × Registration Number 0217U007435, 0117U006276 , R & D reports Title Development of new generation implants is based on synthetic bone tissue analogues and mesenchymal stem cells for bone tissue damage reconstruction. popup.stage_title Head Oksana O. Piven, Кандидат біологічних наук Registration Date 05-01-2018 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 In this project we have focused on creation new type of implantswhat are consisting of synthetic biocompatible and soluble base and patient cells. We aim to develop a new method for obtaining new-generation implants for regeneration of bone tissue injuries of varying severity based on the use of bioactive ceramics and the patient's mesenchymal stem autoclit (MSC). Such implants are a combination of advances in modern material science and cell biology. During the first phase of the project implementation, according to the schedule, we have optimized methods for the mesenchymal stem cells isolation from adipose tissue and bone marrow of rats for further work . The materials we received from mesenchymal stem cells were carefully characterized, namely, they showed the MSC genes markers (CD90, CD105 CD73) expression and do not express the pluripotent cell marker (Sox2). These data indicate that the isolated cells are mesenchymal stem cells. They also analyzed their differential potential (ability to give rise to bone, muscle and adipose tissue). In addition, we developed a technology for applying and growing the cell material we received on the granules of bioactive ceramics. On the basis of the analysis of literary data, we developed a theory of the osteogenic action of bioactive ceramics on the differentiation of stem cells. Product Description popup.authors Балацький Володимир Вікторович Мацевич Лариса Леонідівна Рубан Тетяна Афанасівна Суліковська Інна Олександрівна popup.nrat_date 2020-04-02 Close