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Information × Registration Number 0218U000051, 0116U002095 , R & D reports Title The development of supporting therapy in patients with leukemia who receive intensive chemotherapy. popup.stage_title Head Starikov A.V., Registration Date 16-01-2018 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 The subject of the study was 25 patients with acute leukemia who underwent 34 courses of high-dose chemotherapy. It was found that the toxic effect of chemotherapy is already on the third day after the start of the course of high-dose chemotherapy, reaches a maximum on the 9th day and decreases somewhat under the influence of detoxification infusion therapy and the use of hepatoprotectors of direct action (hepasol, hepa-mertz) on day 14. It is assumed that the greatest lesions of the gastrointestinal tract are observed in patients who received high doses of methotrexate in the course of cytostatic therapy and the most pronounced intoxication and disturbances in the functional state of the liver and kidneys were determined in patients who were simultaneously administered high doses of methotrexate and cytorabine. Medicine Product Description popup.authors Баронська Лілія Володимирівна Кисельова Олена Анатоліївна popup.nrat_date 2020-04-02 Close