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Information × Registration Number 0218U000119, 0115U003300 , R & D reports Title To examine the course of ulcerative colitis in children and to establish predictors of disease progression popup.stage_title Head Denysova Margaryta; Tshypkun Anatoliy, Registration Date 22-01-2018 Organization State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine" popup.description2 For the first time, the multifactor principle – clinical disease activity (pediatric activity index), fecal calprotectin concentration, histological criteria of activity, L-arginine-NO system condition specifics, life quality indicators - was utilized in the methods of examination of children with ulcerative colitis to establish the diagnosis and determine the disease progression, which contributed to improving the diagnostics and allowed forecasting the disease progression. Analysis of clinical and paraclinic progression of ulcerative colitis enabled us to single out the two phenotypes of the disease: chronic recurrent (favorable progression) and chronic continuous (unfavorable progression). The histological criteria of activity of inflammatory process in the intestines and the criteria of disease progression prognosis were developed for the first time for the children suffering from ulcerative colitis. It has been proved that the morphological substrate of unfavorable progression of the disease (continuous form) is the combination of morphological markers of high activity inflammatory process in the bowels with early chronicity sings. For the first time, the approaches to pathogenetic therapy were developed based on determining the disease phenotypes and progression in children with ulcerative colitis at early stages of examination. Diagnostics of the continuous form of ulcerative colitis in course of primary examination of the patient determine the relevancy of the combination therapy indications, which makes remission possible at earlier times. It has been evidenced that the quality of life of ulcerative colitis patients depends on the degree of inflammation severity, localization of the lesions, and morbidity. The optimization directions of the modern guidelines regarding diagnostics and treatment of ulcerative colitis in children were substantiated in order to provide higher quality medical assistance to the children with this kind of pathology Product Description popup.authors Арчакова Т.М. Букулова Н.Ю. Задорожна Т.Д. Касянчук Н. Лисяна Т.О. Музика Н.М. Ткалик О. Чернега Н.В. popup.nrat_date 2020-04-02 Close