Search academic texts

Information × Registration Number 0218U000133, 0116U002641 , R & D reports Title Complexation of С60 Fullerene with Drug Preparations to Increase the Efficiency of Anticancer Therapy popup.stage_title Head Мykhailenko Оleksiy, Registration Date 22-01-2018 Organization Taras Shevchenko Kiev University popup.description2 Object of research: electron-conformational transformation and due to it the change of therapeutic properties of nanocomplexes of molecules of drug antineoplastic preparations with fullerene C60. The purpose of the work was to create and characterize the bioavailable form of complexes of carbon nanostructures of fullerene C60 with cisplatin / conium and an experimental substantiation of the possibility of using these nanocomplexes to increase the antitumor efficacy of cisplatin / conium, suppressing the resistance of tumor cells to their action and reducing the side effects of toxicity.Methods of research: quantum-chemical calculations and determination of kinetic and thermodynamic parameters of complex formation in the system of fullerene C60 - cyclatin / konium; the creation on their basis of therapeutic nanocomplexes in a bioavailable form to increase the effectiveness of their antitumor action, targeted delivery to target cells, and reduce the side effects of toxic effects on the cell and organ levels. Product Description popup.authors Губрій Богдан Олександрович Заводовський Данило Олександрович Михайленко Олексій Володимирович Петрусенко Світлана Романівна Прилуцький Юрій Іванович popup.nrat_date 2020-04-02 Close