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Information × Registration Number 0218U000178, 0115U003476 , R & D reports Title To explore the features of corrective action of stem cells on pathologically altered tissue structures and functions in animals-recipient popup.stage_title Head Mazurkevych Anatoliy, Registration Date 23-01-2018 Organization National university of Life and Environmental Sciences of Ukraine popup.description2 The object of the study is the immunophenotype and genetic features of cell cultures during the process of cultivation, destructive processes in the tissues of the tendon and pancreas, the reparative processes in the organism of recipient animals under the influence of stem cells, changes in the organism of laboratory animal with tumor cells under the influence of allogenic mesenchymal stem cells, the method of obtaining the primary material and its processing for the cultivation of stem cells from the bone marrow, fatty, nerve tissue and pancreas, lipids of the stem cells pathomorphological changes in animals with Lewis lung carcinoma under the impact of stem cell, changes in animals with experimental diabetes and hypothyroidism under the influence of allogeneic cell culture, regenerative processes in the tissue under the influence of stem cells. The purpose of the study was to investigate the quantitative and qualitative changes of the chromosomal apparatus of mesenchymal stem cells of bone marrow of rabbits at early cultivating passages with different methods of cellular dissociation; to study the histological changes in the tendons of laboratory animals after the simulation of the pathological process; to study the histological changes in the pancreas in experimental diabetes mellitus; to study the effect of allogenic mesenchymal stromal cells of the bone marrow of animals on the restoration of the degenerate damaged Achilles tendon of rabbits; to study the pathomorphological changes in the organism of laboratory animals with tumor under the influence of allogenic mesenchymal stem cells; to determine the pathomorphological changes of the structure of primary tumor tissue in mice with transplanted Lewis lung carcinoma under influence of mesenchymal stem cells; to investigate the properties of stem cells derived from the primary biological material (fat, nervous tissue, bone marrow) of animals of different species; to study the pathomorphological changes in the organism of laboratory animals with experimental diabetes mellitus; compare the different compositional culture media on the proliferative activity of the culture of bone marrow cells; to investigate the phenotypic changes in cultures of adipose tissue, bone marrow and pancreas during the process of cultivation; to investigate the cytogenetic changes in cultures of adipose tissue, bone marrow and pancreas in the process of cultivation; to follow changes in the organism of animals-recipients with experimental diabetes after the influence of allogenic cultures of cells (bone marrow, adipose tissue and pancreas); to investigate the regularity and nature of changes in biochemical parameters associated with the dynamics of regenerative processes in experimentally damaged bone tissue of rabbits; to study the functional ability of the regenerated thyroid gland to synthesize T4 in rats that were administered with allogeneic stem cells. Methods of research - surgical, biotechnological, cytological, cytogenetic, histological, immunocytochemical, biochemical, statistical.5481 Product Description popup.authors Бокотько Роман Романович Данілов Василь Бенедиктович Кладницька Лариса Володимирівна Ковпак Віталій Васильович Мазуркевич Анатолій Йосипович Малюк Микола Олексійович Савчук Тарас Любомирович Харкевич Юрій Олександрович popup.nrat_date 2020-04-02 Close