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Information × Registration Number 0218U000384, 0116U001003 , R & D reports Title The investigation of cytogenetic effects peculiarities in radiotherapy patients due to different volume and regimen of irradiation popup.stage_title Head Maznyk N.O., Registration Date 26-01-2018 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 Object of study: cytogenetic effects in cultured peripheral blood lymphocytes of cancer patients during radiation therapy with various exposure regimen. The aim: to assess the cytogenetic effects in vivo and ex vivo in lymphocytes of cancer patients following external and internal radiation treatment, depending on the irradiation volume and exposure regimen. Research methods and techniques: cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, microscopes Axioskop, Micros MC300X and Olympus, system ASIS. Theoretical and practical results: it was shown the excess of chromosome aberrations before treatment over spontaneous level in all groups of patients. The highest level of chromosomal lesions was found in lung cancer patients. The high informativity of in vivo cytogenetic test for the detection of partial-body exposure in early radiotherapy stage was demonstrated. A significant increase of the chromosome aberrations level at the end of therapy was shown, its degree depended on the tumor localization, the highest rates were found in groups of oncogynecological cancer patients. These data are of importance for correct assessing the impact of therapeutic irradiation on normal tissues at the chromosomal level. Novelty: new knowledge was obtained about the character of chromosome damage outcome in lymphocytes of cancer patients in early and late stages of radiation therapy depending on the exposure regimen. The effectiveness of implementation: is not present. Area of application: radiobiology, radiation therapy, biological dosimetry. Product Description popup.authors Гайсенюк Л.О. Дашкова С.А. Колпакова Л.К. Мазник Н.О. Павліченко Ю.В. Пшенічна Н.Д. Пшишевська Л.А. Святенко Н.І. Сипко Т.С. Старенький В.П. Сухіна О. М. popup.nrat_date 2020-04-02 Close