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Information × Registration Number 0218U000387, 0117U001045 , R & D reports Title Define the role of the cyclooxygenase-2 selective inhibitor along with the ionizing radiation in blocking of tumor angiogenesis for development of new technologies of the combined radiation and anti-angiogenesis therapy of oncological diseases popup.stage_title Head Starenkiy V.P., Mitryaeva N.A., Registration Date 26-01-2018 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 Object of research: determination of VEGF, cyclooxygenase-2 (COX-2), prostaglandin E-2 (PGE-2) levels in the blood serum of oncologic patients in the dynamics of radiotherapy. Experimental study of the effect of X-radiation and the combined effect of X-radiation and COX-2 inhibitor-meloksyvet on the content of VEGF and PGE-2. Objective: to determine the mechanisms of participation of selective inhibitors of cyclooxygenase-2 in combination with ionizing radiation in the blocking of tumor angiogenesis to substantiate their role in radiation therapy of cancer diseases and to develop recommendations for new technologies of combined radiation and antianginal therapy for lung and laryngeal cancer. Methods of research and equipment: clinical and instrumental, immunoenzymometric, electron-microscopic, dosimetric, statistical; the immunoenzymometric analyzer Immunochem-2100, sliding microtome MC-2, the universal dosimeter UNIDOS_E, the linear accelerator Clinac-600, RUM-17. Theoretical and practical results. Mechanisms of the combined effect of irradiation and the COX-2 inhibitor (meloksyvet) on the blocking of tumor angiogenesis have been determined. It is proved that the maintenance of VEGF in blood serum of 89% of patients with non-small cell lung cancer (NSCLC) and 91% of patients with tumors of the head and a neck (THN) prior to conformal radiation therapy is higher than in experimental group. The scientific data on the dynamic changes of VEGF rates in serum of patients with NSCLC and THN has been refined to an objective response in radiotherapy, which have practical importance for treatment planning. Novelty: for the first time it has been proved that the levels of COX-2 and PGE-2 in the blood serum of 83.3% of NSCLC patients and 86.4% of patients with THN were elevated to radiation therapy and remain high after treatment. Experimentally, in rats with a transplanted Guerin tumor, it has been established that the combined effect of X-radiation and meloksyvet affects the level of PGE-2 and VEGF, which is associated with inhibition of COX-2 and indicates a mechanism of combined action of the irradiation and inhibitor of COX-2 to block tumor angiogenesis. Efficiency of implementation: assessment improvement of conformal radiation therapy effectiveness in patients with non-small cell lung cancer and head and neck tumors in order to select adequate treatment. Domain of usage: medical radiology and oncology. Product Description popup.authors Артамонова Н.О. Артюх С.В. Білозор Н.В. Гребіник Л.В. Канцедал О.М. Карвасарська В.В. Куров О.М. Лукашова О.П. Мітряєва Н.А. Макрук О.В. Маслєннікова О.Л. Потапова Т.І. Пшишевська Л.А. Спузяк Р.М. Старенький В.П. Тесленко І.М. Ткаченко А.А. Узлєнкова Н.Є. popup.nrat_date 2020-04-02 Close