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Information × Registration Number 0218U000888, 0115U005604 , R & D reports Title Investigation of the mechanisms of glioma chemoresistance and development of the approaches to glioma complex therapy popup.stage_title Head Avdieiev Stanislav Sergeevich, Registration Date 26-02-2018 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Short antisense nucleotides, namely, short interfering RNAs (siRNA_CHI3L1) and morpholino-oligonucleotides (MO_CHI3L1) to inhibit the production of the CHI3L1 protein, were synthesized. It has been shown that inhibition of CHI3L1 production significantly increases the sensitivity of the glioma cell lines to temozolomide which can be used to develop complex approaches to the therapy of tumors that produce CHI3L1. The variants of the human glioblastoma line, as well as cells with CHI3L1 overproduction, and a number of their phenotypic characteristics, namely, proliferation, migration, invasion, growth in soft agar and sensitivity to glucose level, were obtained for temozolomide. It was shown that prolonged treatment with the cytotoxic clinical preparation temozolomide results in a variety and multidirectional changes in the phenotype of tumor cells, which may possibly be responsible for the heterogeneity of the tumor response to therapy5481 Product Description popup.authors Єршов Антон Вікторович Арешков Павло Олександрович Степаненко Олексій Анатолійович Чаусовський Тімур Йосипович popup.nrat_date 2020-04-02 Close