Search academic texts

Information × Registration Number 0218U001387, 0116U007815 , R & D reports Title Study of biological characteristics of endometrial cancer and determination of endometrioid carcinoma molecular subtypes associated with high malignant potential popup.stage_title Head Buchynska Liubov Georgiivna, Доктор біологічних наук Registration Date 07-02-2018 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Aneuploid DNA profile was detected in 15.8% tumors of patients with endometrial cancer, that was in correlation with a decrease in the expression of epithelial-mesenchymal transition markers (E-cadherin and vimentin proteins) and over-expression of c-myc protein, compared to those with diploid endometrial tumors, which was associated with a low degree of differentiation, high proliferative potential and deep myometrial invasion. The obtained data reflect the morpho-genetic heterogeneity of endometrioid carcinomas of endometrium, that is the basis for the determination of more aggressive molecular subtypes of this form of cancer and point the need of personified treatment for such patients. Product Description popup.authors Брєєва О.В. Бучинська Л.Г. Глущенко Н.М. Кашуба О.В. Несіна І.П. Юрченко Н.П. popup.nrat_date 2020-04-02 Close